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SMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta

SMER28 (Small molecule enhancer of Rapamycin 28) is an autophagy-inducing compound functioning by a hitherto unknown mechanism. Here, we confirm its autophagy-inducing effect by assessing classical autophagy-related parameters. Interestingly, we also discovered several additional effects of SMER28,...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Marco Kirchenwitz, Stephanie Stahnke, Silvia Prettin, Malgorzata Borowiak, Laura Menke, Christian Sieben, Carmen Birchmeier, Klemens Rottner, Theresia E. B. Stradal, Anika Steffen
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-05-01
Schriftenreihe:Cells
Schlagworte:
phosphatidylinositol 3-kinase (PI 3-kinase)
mammalian target of rapamycin (mTOR)
autophagy
receptor tyrosine kinase
small molecule
actin
Online-Zugang:https://www.mdpi.com/2073-4409/11/10/1648
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