A novel nanomedicine for osteosarcoma treatment: triggering ferroptosis through GSH depletion and inhibition for enhanced synergistic PDT/PTT therapy

Abstract Osteosarcoma treatment remains challenging due to the limitations of single-modality therapies. To address this, we designed a carrier-free nanomedicine SRF@CuSO4.5H2O@IR780 (CSIR) for synergistic ferroptosis, photodynamic therapy (PDT), and photothermal therapy (PTT) in osteosarcoma. Inter...

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Hlavní autoři:	Tangbing Xu, Qiming Ma, Chi Zhang, Xiaoyan He, Qian Wang, Yunfeng Wu, Kunpeng Qin, Faxue Liao, Ping Zhou, Pengfei Xu, Jialai Yang, Junjun Yang, Jun Chang, Lei Qiao, Yong Hu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-04-01
Edice:	Journal of Nanobiotechnology
Témata:	Carrier-free nanomedicine Osteosarcoma Ferroptosis PDT/PTT Therapy Reactive oxygen species
On-line přístup:	https://doi.org/10.1186/s12951-025-03380-4
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