An evolutionarily conserved function of C-reactive protein is to prevent the formation of amyloid fibrils

C-reactive protein (CRP) binds to phosphocholine (PCh)-containing substances and subsequently activates the complement system to eliminate the ligand. The PCh-binding function of CRP has been conserved throughout evolution from arthropods to humans. Human CRP, in its structurally altered conformatio...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Alok Agrawal, Asmita Pathak, Donald N. Ngwa, Avinash Thirumalai, Peter B. Armstrong, Sanjay K. Singh
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-09-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	C-reactive protein Limulus polyphemus American horseshoe crab amyloidosis protein toxicity
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466865/full
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