An evolutionarily conserved function of C-reactive protein is to prevent the formation of amyloid fibrils

C-reactive protein (CRP) binds to phosphocholine (PCh)-containing substances and subsequently activates the complement system to eliminate the ligand. The PCh-binding function of CRP has been conserved throughout evolution from arthropods to humans. Human CRP, in its structurally altered conformatio...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Alok Agrawal, Asmita Pathak, Donald N. Ngwa, Avinash Thirumalai, Peter B. Armstrong, Sanjay K. Singh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-09-01
coleção:	Frontiers in Immunology
Assuntos:	C-reactive protein Limulus polyphemus American horseshoe crab amyloidosis protein toxicity
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466865/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!