The ESCRT-III molecules regulate the apical targeting of bile salt export pump

Abstract Background The bile salt export pump (BSEP) is a pivotal apical/canalicular bile salt transporter in hepatocytes that drives the bile flow. Defects in BSEP function and canalicular expression could lead to a spectrum of cholestatic liver diseases. One prominent manifestation of BSEP-associa...

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Prif Awduron:	Shang-Hsin Wu, Mei-Hwei Chang, Ya-Hui Chen, Hui-Lin Wu, Huey-Huey Chua, Chin-Sung Chien, Yen-Hsuan Ni, Hui-Ling Chen, Huey-Ling Chen
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2021-03-01
Cyfres:	Journal of Biomedical Science
Pynciau:	Apical trafficking Bile salt export pump Cholestasis CHMP5 ESCRT Liver development
Mynediad Ar-lein:	https://doi.org/10.1186/s12929-020-00706-2
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