Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome

Exosome is an excellent vesicle for in vivo delivery of therapeutics, including RNAi and chemical drugs. The extremely high efficiency in cancer regression can partly be attributed to its fusion mechanism in delivering therapeutics to cytosol without endosome trapping. However, being composed of a l...

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Hlavní autoři:	Nasir Uddin, Daniel W. Binzel, Dan Shu, Tian-Min Fu, Peixuan Guo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2023-04-01
Edice:	Acta Pharmaceutica Sinica B
Témata:	RNA interference RNA nanotechnology Endolysosome trapping Exosome engineering Targeted delivery Chemical drug delivery
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211383522004865
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