Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model

Botulinum neurotoxins (BoNT) are some of the most toxic proteins known, with a human LD₅₀ of ~1 ng/kg. Equine antitoxin has a half-life in circulation of less than 1 day and is limited to a treatment rather than a prevention indication. The development of monoclonal antibodies (mAbs) may...

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Hlavní autoři:	Milan T. Tomic, Yero Espinoza, Zachary Martinez, Khanh Pham, Ronald R. Cobb, Doris M. Snow, Christopher G. Earnhart, Traci Pals, Emily S. Syar, Nancy Niemuth, Dean J. Kobs, Shauna Farr-Jones, James D. Marks
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2019-04-01
Edice:	Toxins
Témata:	botulinum neurotoxin aerosol monoclonal antibody guinea pig inhalation model oligoclonal antibody inhalational botulism botulism
On-line přístup:	https://www.mdpi.com/2072-6651/11/4/208
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