PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway

A classical hallmark of Parkinson’s disease (PD) pathogenesis is the accumulation of misfolded alpha-synuclein (αSyn) within Lewy bodies and Lewy neurites, although its role in microglial dysfunction and resultant dopaminergic (DAergic) neurotoxicity is still elusive. Previously, we identified that...

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Main Authors:	Manikandan Samidurai, Bharathi N. Palanisamy, Alejandra Bargues-Carot, Monica Hepker, Naveen Kondru, Sireesha Manne, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Anumantha G. Kanthasamy, Arthi Kanthasamy
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Aging Neuroscience
Subjects:	ER stress TXNIP NLRP3 PKCδ Parkinson’s disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.661505/full
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