Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor
ABSTRACT Polycomb Repressive Complex 2 (PRC2), containing homologous EZH1 or EZH2 as the catalytic subunit, is a conserved methyltransferase complex that represses gene transcription by transferring methyl group from SAM to H3K27. Gain‐of‐function mutations of EZH2 and aberrant H3K27 methylation hav...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Wiley
2026-09-01
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| Serie: | Advanced Science |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1002/advs.76025 |
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