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Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

ABSTRACT Polycomb Repressive Complex 2 (PRC2), containing homologous EZH1 or EZH2 as the catalytic subunit, is a conserved methyltransferase complex that represses gene transcription by transferring methyl group from SAM to H3K27. Gain‐of‐function mutations of EZH2 and aberrant H3K27 methylation hav...

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Principais autores: Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-09-01
Serier:Advanced Science
Fag:
allosteric mechanism
cancer immunotherapy
EZH2 inhibitor
PRC2
Online adgang:https://doi.org/10.1002/advs.76025
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