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Nilotinib hydrochloride monohydrate solubility in supercritical carbon dioxide + cosolvent: measurements and modeling

Abstract The solubility of nilotinib hydrochloride monohydrate in supercritical CO₂ was measured at four temperatures between 338 K and 308 K, and seven pressures between 12 MPa and 30 MPa, using ethanol as a cosolvent. Both semi-empirical and empirical approaches were employed to analyze the experi...

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Autors principals: Seyed Ali Sajadian, Adel Noubigh, Mahshid Askarizadeh, L. Antonio Estévez
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2025-10-01
Col·lecció:Scientific Reports
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Accés en línia:https://doi.org/10.1038/s41598-025-20081-y
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