Nilotinib hydrochloride monohydrate solubility in supercritical carbon dioxide + cosolvent: measurements and modeling

Abstract The solubility of nilotinib hydrochloride monohydrate in supercritical CO₂ was measured at four temperatures between 338 K and 308 K, and seven pressures between 12 MPa and 30 MPa, using ethanol as a cosolvent. Both semi-empirical and empirical approaches were employed to analyze the experi...

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Hlavní autoři:	Seyed Ali Sajadian, Adel Noubigh, Mahshid Askarizadeh, L. Antonio Estévez
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-10-01
Edice:	Scientific Reports
Témata:	Nilotinib hydrochloride monohydrate Solubility measurement Supercritical carbon dioxide Cosolvent Semi-empirical modeling
On-line přístup:	https://doi.org/10.1038/s41598-025-20081-y
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