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Effective holistic characterization of small molecule effects using heterogeneous biological networks

The two most common reasons for attrition in therapeutic clinical trials are efficacy and safety. We integrated heterogeneous data to create a human interactome network to comprehensively describe drug behavior in biological systems, with the goal of accurate therapeutic candidate generation. The Co...

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Autores principales: William Mangione, Zackary Falls, Ram Samudrala
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2023-04-01
Colección:Frontiers in Pharmacology
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Acceso en línea:https://www.frontiersin.org/articles/10.3389/fphar.2023.1113007/full
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