LICHEN enables light-chain immunoglobulin sequence generation conditioned on the heavy chain and experimental needs

Abstract In developing therapeutic antibodies, the heavy chain is often prioritised due to its higher variability and its central role in antigen binding. An appropriate pairing of the light sequence is however important for antibody function. Here we present LICHEN, a heavy chain conditioned light...

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Detalles Bibliográficos

Principais autores:	Henriette L. Capel, Isaac Ellmen, Chris J. Murray, Giulia Mignone, Megan Black, Brendan Clarke, Conor Breen, Sean Tierney, Patrick Dougan, Richard J. Buick, Alexander Greenshields-Watson, Charlotte M. Deane
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Series:	Communications Biology
Acceso en liña:	https://doi.org/10.1038/s42003-026-09727-3
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