LICHEN enables light-chain immunoglobulin sequence generation conditioned on the heavy chain and experimental needs
Abstract In developing therapeutic antibodies, the heavy chain is often prioritised due to its higher variability and its central role in antigen binding. An appropriate pairing of the light sequence is however important for antibody function. Here we present LICHEN, a heavy chain conditioned light...
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| Principais autores: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2026-02-01
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| coleção: | Communications Biology |
| Acesso em linha: | https://doi.org/10.1038/s42003-026-09727-3 |
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