Deletion of the ATP2 Gene in Candida albicans Blocks Its Escape From Macrophage Clearance

Macrophages provide the first-line defense against invasive fungal infections and, therefore, escape from macrophage becomes the basis for the establishment of Candida albicans invasive infection. Here, we found that deletion of ATP2 (atp2Δ/Δ) in C. albicans resulted in a dramatic decrease from 69.2...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yishan Zhang, Chuanyan Tang, Zhanpeng Zhang, Shuixiu Li, Yajing Zhao, Luobei Weng, Hong Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-04-01
Schriftenreihe:	Frontiers in Cellular and Infection Microbiology
Schlagworte:	Candida albicans ATP2 gene macrophage host-pathogen interaction alternative carbon source glyoxylate cycle
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fcimb.2021.643121/full
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