Sulforaphane Inhibits Lipopolysaccharide-Induced Inflammation, Cytotoxicity, Oxidative Stress, and miR-155 Expression and Switches to Mox Phenotype through Activating Extracellular Signal-Regulated Kinase 1/2–Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway in Murine Microglial Cells

Sulforaphane (SFN) is a natural product with cytoprotective, anti-inflammatory, and antioxidant effects. In this study, we evaluated the mechanisms of its effects on lipopolysaccharide (LPS)-induced cell death, inflammation, oxidative stress, and polarization in murine microglia. We found that SFN p...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Erden Eren, Kemal Ugur Tufekci, Kamer Burak Isci, Bora Tastan, Kursad Genc, Sermin Genc
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2018-01-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	sulforaphane microglia lipopolysaccharide nuclear factor erythroid 2-related factor 2 Mox phenotype miR-155
Онлайн хандалт:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00036/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!