Generation of an iPSC line IUFi004-A-13 with homozygous NDUFS1 mutation for the study of Leigh syndrome

NDUFS1 is a critical component of mitochondrial respiratory chain Complex I (CI). Pathogenic variants of NDUFS1 can cause Leigh syndrome (LS), a severe pediatric mitochondrial disorder. To model NDUFS1-linked LS, we generated an iPSC line with homozygous missense mutations in exon 8 using CRISPR/Cas...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	Caleb Jerred, Haribaskar Ramachandran, Barbara Hildebrandt, Annika Zink, Natascia Ventura, Andrea Rossi, Alessandro Prigione
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2026-08-01
Cyfres:	Stem Cell Research
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S187350612600098X
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!