CRISPR/Cas9-mediated editing of MIC13 in human induced pluripotent stem cells: A model for mitochondrial hepato-encephalopathy

MIC13 is essential for cristae formation and functions as a key component of the large mitochondrial multi subunit MICOS complex. Mutations in MIC13 causes severe mitochondrial disease called mitochondrial hepato-encephalopathy. In this study, we describe the generation of a human induced pluripoten...

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Detalhes bibliográficos

Principais autores:	Haribaskar Ramachandran, Alexander Becker, Jochen Dobner, Barbara Hildebrandt, Felix Distelmaier, Andrea Rossi, Ruchika Anand
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-12-01
coleção:	Stem Cell Research
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S187350612500220X
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