Plasma pQTL and brain eQTL integration identifies PNKP as a therapeutic target and reveals mechanistic insights into migraine pathophysiology

Abstract Background Migraine is a prevalent neurological disorder affecting 14.1% of the global population. Despite advances in genetic research, further investigation is needed to identify therapeutic targets and better understand its mechanisms. In this study, we aimed to identify drug targets and...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Jiafei Lou, Miaoqian Tu, Maosheng Xu, Zhijian Cao, Wenwen Song
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-11-01
Edice:	The Journal of Headache and Pain
Témata:	Migraine Mendelian randomization Gene regulation Protein expression Metabolic pathways Drug development
On-line přístup:	https://doi.org/10.1186/s10194-024-01922-z
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!