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Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies

DNA adducts, which block replicative DNA polymerases (DNAPs), are often bypassed by lesion-bypass DNAPs, which are mostly in the Y-Family. Y-Family DNAPs can do non-mutagenic or mutagenic dNTP insertion, and understanding this difference is important, because mutations transform normal into tumorige...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Sushil Chandani, Christopher Jacobs, Edward L. Loechler
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Wiley 2010-01-01
Rangatū:Journal of Nucleic Acids
Urunga tuihono:http://dx.doi.org/10.4061/2010/784081
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