PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.

Replicative DNA polymerases are frequently stalled at damaged template strands. Stalled replication forks are restored by the DNA damage tolerance (DDT) pathways, error-prone translesion DNA synthesis (TLS) to cope with excessive DNA damage, and error-free template switching (TS) by homologous DNA r...

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Autores principales:	Masataka Tsuda, Saki Ogawa, Masato Ooka, Kaori Kobayashi, Kouji Hirota, Mitsuo Wakasugi, Tsukasa Matsunaga, Tetsushi Sakuma, Takashi Yamamoto, Shunsuke Chikuma, Hiroyuki Sasanuma, Michelle Debatisse, Aidan J Doherty, Robert P Fuchs, Shunichi Takeda
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2019-01-01
Colección:	PLoS ONE
Acceso en línea:	https://doi.org/10.1371/journal.pone.0213383
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