Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition

Abstract Defense-associated reverse transcriptase (DRT) systems are implicated in prokaryotic resistance to viral infections, yet the molecular mechanisms underlying their functionality remain largely unknown. Here, we characterize a two-component DRT9 system, composed of a reverse transcriptase (RT...

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Autors principals:	Jie Han, Bin Liu, Jingjing Tang, Shuqin Zhang, Xiaoshen Wang, Xuzichao Li, Qian Zhang, Zhikun Liu, Wanyao Wang, Yingcan Liu, Ruimin Zhou, Hang Yin, Yong Wei, Zhuang Li, Minjie Zhang, Zengqin Deng, Heng Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2025-08-01
Col·lecció:	The EMBO Journal
Matèries:	Reverse Transcriptase DRT9 Non-coding RNA Protein-Primed cDNA Synthesis Bacterial Antiviral Defense
Accés en línia:	https://doi.org/10.1038/s44318-025-00544-8
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