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Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition

Abstract Defense-associated reverse transcriptase (DRT) systems are implicated in prokaryotic resistance to viral infections, yet the molecular mechanisms underlying their functionality remain largely unknown. Here, we characterize a two-component DRT9 system, composed of a reverse transcriptase (RT...

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Principais autores: Jie Han, Bin Liu, Jingjing Tang, Shuqin Zhang, Xiaoshen Wang, Xuzichao Li, Qian Zhang, Zhikun Liu, Wanyao Wang, Yingcan Liu, Ruimin Zhou, Hang Yin, Yong Wei, Zhuang Li, Minjie Zhang, Zengqin Deng, Heng Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2025-08-01
Serier:The EMBO Journal
Fag:
Reverse Transcriptase
DRT9
Non-coding RNA
Protein-Primed cDNA Synthesis
Bacterial Antiviral Defense
Online adgang:https://doi.org/10.1038/s44318-025-00544-8
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