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Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine

Abstract The exact mechanisms that trigger the activation of the trigeminovascular system in migraine remain unclear. The involvement of calcitonin gene-related peptide (CGRP) in migraine is well-documented, and treatments aimed at blocking CGRP activity have proven successful in reducing migraine a...

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Bibliografiske detaljer
Principais autores: Fahimeh Martami, Kathleen F. Holton
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-05-01
Serier:The Journal of Headache and Pain
Fag:
Online adgang:https://doi.org/10.1186/s10194-025-02043-x
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