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Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity

Our previous studies identified that retinal endothelial damage caused by hyperglycemia or nucleoside diphosphate kinase-B (NDPK-B) deficiency is linked to elevation of angiopoietin-2 (Ang-2) and the activation of the hexosamine biosynthesis pathway (HBP). Herein, we investigated how NDPK-B is invol...

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Principais autores: Anupriya Chatterjee, Rachana Eshwaran, Gernot Poschet, Santosh Lomada, Mahmoud Halawa, Kerstin Wilhelm, Martina Schmidt, Hans-Peter Hammes, Thomas Wieland, Yuxi Feng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-10-01
coleção:Cells
Assuntos:
nucleoside diphosphate kinase B
Ang-2
O-GlcNAcylation
UDP-GlcNAc
OGA
Acesso em linha:https://www.mdpi.com/2073-4409/9/10/2324
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