Synthesis of chiral N-phosphinyl α-imino esters and their application in asymmetric synthesis of α-amino esters by reduction

A variety of chiral N-phosphinyl α-imino esters have been synthesized for the first time from ketoesters and phosphinylamide, which were then reduced by L-selectride to give the corresponding N-phosphinyl-protected α-amino esters. The reduction proceeded very well with excellent chemical yields (88–...

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Autors principals:	Yiwen Xiong, Haibo Mei, Lingmin Wu, Jianlin Han, Yi Pan, Guigen Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Beilstein-Institut 2014-03-01
Col·lecció:	Beilstein Journal of Organic Chemistry
Matèries:	α-amino ester α-imino ester group-assisted purification phosphinyl auxiliary reduction
Accés en línia:	https://doi.org/10.3762/bjoc.10.57
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