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In situ monolayer patch clamp of acutely stimulated human iPSC-derived cardiomyocytes promotes consistent electrophysiological responses to SK channel inhibition

Abstract Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) represent an in vitro model of cardiac function. Isolated iPSC-CMs, however, exhibit electrophysiological heterogeneity which hinders their utility in the study of certain cardiac currents. In the healthy adult heart, the...

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Autores principales: Andrew S. Butler, Raimondo Ascione, Neil V. Marrion, Stephen C. Harmer, Jules C. Hancox
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2024-02-01
Colección:Scientific Reports
Acceso en línea:https://doi.org/10.1038/s41598-024-53571-6
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