High-throughput screening identifies Aurora kinase B as a critical therapeutic target for Merkel cell carcinoma

Abstract Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. Most MCCs contain Merkel cell polyomavirus (virus-positive MCC; VP-MCC), and the remaining are virus-negative (VN-MCC). Immune checkpoint inhibitors are the first-line treatment for metastatic MCC, but durable responses are achi...

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Detalhes bibliográficos

Principais autores:	Tara Gelb, Khalid A. Garman, Daniel Urban, Amy Coxon, Berkley Gryder, Natasha T. Hill, Lingling Miao, Tobie Lee, Olivia Lee, Sirisha Chakka, John Braisted, Jordan E. Jarvis, Rachael Glavin, Trisha S. Raj, Ying Xiao, Simone Difilippantonio, Amy Q. Wang, Min Shen, Ken Chih-Chien Cheng, Madhu Lal-Nag, Matthew D. Hall, Isaac Brownell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-02-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-56504-7
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