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Continuous Affinity Purification of Adeno-Associated Virus Using Periodic Counter-Current Chromatography

Replacing batch unit operations of biopharmaceuticals by continuous manufacturing is a maturing concept, with periodic counter-current chromatography (PCC) favoured to replace batch chromatography. Continuous affinity capture of adeno-associated virus (AAV) using PCC has the potential to cope with t...

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Main Authors: João P. Mendes, Magnus Bergman, Anita Solbrand, Cristina Peixoto, Manuel J. T. Carrondo, Ricardo J. S. Silva
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
adeno-associated virus
affinity purification
continuous processing
gene therapy
periodic counter-current chromatography
Online Access:https://www.mdpi.com/1999-4923/14/7/1346
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