A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity

AimSelective chemogenetic modulation of locus coeruleus (LC) neurons would allow dedicated investigation of the role of the LC-NA pathway in brain excitability and disorders such as epilepsy. This study investigated the feasibility of an experimental set-up where chemogenetic modification of the bra...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Latoya Stevens, Kristl Vonck, Lars Emil Larsen, Wouter Van Lysebettens, Charlotte Germonpré, Veerle Baekelandt, Chris Van den Haute, Evelien Carrette, Wytse Jan Wadman, Paul Boon, Robrecht Raedt
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-03-01
Schriftenreihe:	Frontiers in Neuroscience
Schlagworte:	locus coeruleus chemogenetics designer receptor exclusively activated by designer drugs unit recording clozapine vagus nerve stimulation
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fnins.2020.00162/full
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