Insights into the Effects of Ligand Binding on Leucyl-tRNA Synthetase Inhibitors for Tuberculosis: In Silico Analysis and Isothermal Titration Calorimetry Validation

Incidences of drug-resistant tuberculosis have become common and are rising at an alarming rate. Aminoacyl t-RNA synthetase has been validated as a newer target against <i>Mycobacterium tuberculosis</i>. Leucyl t-RNA synthetase (LeuRS) is ubiquitously found in all organisms and regulates transcripti...

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Principais autores:	Zia Ur Rehman, Asim Najmi, Khalid Zoghebi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-06-01
coleção:	Biomolecules
Assuntos:	computer-aided drug design virtual screening leucyl t-RNA synthetase inhibition molecular dynamics simulation
Acesso em linha:	https://www.mdpi.com/2218-273X/14/6/711
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