Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a complex neurological disorder characterized by the progressive degeneration of midbrain dopaminergic (mDA) neurons in the substantia nigra (SN). This degeneration disrupts the basal ganglia loops, leading to both motor and non-motor dysfunctions. Cel...

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Detalhes bibliográficos

Principais autores:	Bérengère Ballion, Marie-Laure Bonnet, Sébastien Brot, Afsaneh Gaillard
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-05-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Parkinson’s disease Cell therapy HiPSC Intranigral transplantation Mouse Electrophysiology
Acesso em linha:	https://doi.org/10.1186/s13287-025-04344-z
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