Optimization of self-nanoemulsifying formulations for weakly basic lipophilic drugs: role of acidification and experimental design

ABSTRACT Formulators face great challenges in adopting systematic approaches for designing self-nanoemulsifying formulations (SNEFs) for different drug categories. In this study, we aimed to build-up an advanced SNEF development framework for weakly basic lipophilic drugs, such as cinnarizine (CN)....

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Ngā kaituhi matua:	Ahmad Abdul-Wahhab Shahba, Kazi Mohsin, Fars Kaed Alanazi, Sayed Ibrahim Abdel-Rahman
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Rangatū:	Brazilian Journal of Pharmaceutical Sciences
Ngā marau:	Self-nanoemulsifying formulations/solubility Cinnarizine/lipophilic drugs Acidification/experimental design Solubility enhancement.
Urunga tuihono:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400653&lng=en&tlng=en
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!