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Positioning personal polygenic risk score against the population background

Polygenic risk scores, or PRS, have been widely used across many traits to estimate polygenic risk, pleiotropy, and disease prediction. While PRS has the potential to be simple and informative they are not generally interpretable and not directly comparable between studies. They depend on the specif...

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Autori principali: Valentina Escott-Price, Ganna Leonenko, Karl Michael Schmidt
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2026-06-01
Serie:Research in Statistics
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Accesso online:https://www.tandfonline.com/doi/10.1080/27684520.2026.2685935
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