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A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells

The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin is mainly produced by activated CD8+ T cells and natural killer cells. Recent studies have shown that XCL1-antigen fusion proteins efficiently induce CD8+ T...

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Principais autores: Kazuhiko Matsuo, Kosuke Kitahata, Fumika Kawabata, Momo Kamei, Yuta Hara, Shiki Takamura, Naoki Oiso, Akira Kawada, Osamu Yoshie, Takashi Nakayama
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-11-01
coleção:Frontiers in Immunology
Assuntos:
XCR1
XCL1
cross-presenting DC
CTL
adjuvant
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.02775/full
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