Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice

Abstract Pathogenic CD4+ memory T cells (Tm) sustain chronic inflammation, but mechanisms remain undefined. Here, we identify four donor-type CD4+ Tm subsets in the target tissues of autoimmune-like chronic graft-versus-host disease in mice: Ly108+CD69− stem-like memory T cells (Tsm), Ly108+CD69+ re...

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Bibliografiske detaljer

Principais autores:	Xiaohui Kong, Bixin Wang, Xiwei Wu, Hyejin Cho, Weijia Fu, Qinjian Li, Rong Zhang, Ubaydah Nasri, Moqian Zheng, Alyssa Wu, Hanjun Qin, Joey H. Li, Raju Pillai, Timothy E. O’Sullivan, Ryotaro Nakamura, Paul J. Martin, Yuanzhong Chen, Defu Zeng
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-02-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-026-69975-z
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