Ketamine Increases Proliferation of Human iPSC-Derived Neuronal Progenitor Cells via Insulin-Like Growth Factor 2 and Independent of the NMDA Receptor

The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine offers promising perspectives for the treatment of major depressive disorder. Although ketamine demonstrates rapid and long-lasting effects, even in treatment-resistant patients, to date, the underlying mode of action remains elusive. Thus...

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Autors principals:	Alessandra Grossert, Narges Zare Mehrjardi, Sarah J. Bailey, Mark A. Lindsay, Jürgen Hescheler, Tomo Šarić, Nicole Teusch
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2019-09-01
Col·lecció:	Cells
Matèries:	human iPSC-derived NPCs depression neurogenesis ketamine IGF2 cAMP p11
Accés en línia:	https://www.mdpi.com/2073-4409/8/10/1139
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