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High maternal-fetal HLA eplet compatibility is associated with severe manifestation of preeclampsia

IntroductionPreeclampsia is responsible for more than 70 000 and 500 000 maternal and fetal deaths, respectively each year. Incomplete remodelling of the spiral arteries in placenta is the most accepted theory of preeclampsia pathogenesis. However, the process is complexed with immunological backgro...

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Principais autores: Katarzyna Stefańska, Małgorzata Kurkowiak, Karolina Piekarska, Elżbieta Chruściel, Dorota Zamkowska, Joanna Jassem-Bobowicz, Przemysław Adamski, Renata Świątkowska-Stodulska, Anna Abacjew-Chmyłko, Katarzyna Leszczyńska, Maciej Zieliński, Krzysztof Preis, Hanna Zielińska, Bogusław Tymoniuk, Piotr Trzonkowski, Natalia Maria Marek-Trzonkowska
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-11-01
Colecção:Frontiers in Immunology
Assuntos:
preeclampsia
gestational hypertension
HLA eplet mismatch load
maternal-fetal HLA compatibility
maternal-fetal immune tolerance
immunology of pregnancy
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1272021/full
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