High maternal-fetal HLA eplet compatibility is associated with severe manifestation of preeclampsia

IntroductionPreeclampsia is responsible for more than 70 000 and 500 000 maternal and fetal deaths, respectively each year. Incomplete remodelling of the spiral arteries in placenta is the most accepted theory of preeclampsia pathogenesis. However, the process is complexed with immunological backgro...

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Главные авторы:	Katarzyna Stefańska, Małgorzata Kurkowiak, Karolina Piekarska, Elżbieta Chruściel, Dorota Zamkowska, Joanna Jassem-Bobowicz, Przemysław Adamski, Renata Świątkowska-Stodulska, Anna Abacjew-Chmyłko, Katarzyna Leszczyńska, Maciej Zieliński, Krzysztof Preis, Hanna Zielińska, Bogusław Tymoniuk, Piotr Trzonkowski, Natalia Maria Marek-Trzonkowska
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2023-11-01
Серии:	Frontiers in Immunology
Предметы:	preeclampsia gestational hypertension HLA eplet mismatch load maternal-fetal HLA compatibility maternal-fetal immune tolerance immunology of pregnancy
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1272021/full
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