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Surveying the Proteome-Wide Landscape of Mitoxantrone and Examining Drug Sensitivity in BRCA1-Deficient Ovarian Cancer Using Quantitative Proteomics

<b>Background</b>: Mitoxantrone (MX) is regularly used to treat several cancers. Despite its long history in the clinic, recent studies continue to unveil novel protein targets. These targets may contribute to the cytotoxic effects of the drug, as well as potential non-canonical antitumor activity....

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Autori principali: Savanna Wallin, Sneha Pandithar, Sarbjit Singh, Siddhartha Kumar, Amarnath Natarajan, Gloria E. O. Borgstahl, Nicholas Woods
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2025-11-01
Serie:Proteomes
Soggetti:
mitoxantrone
homologous recombination-deficiency
ovarian cancer
BRCA1
DNA repair
proteomics
Accesso online:https://www.mdpi.com/2227-7382/13/4/61
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