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Surveying the Proteome-Wide Landscape of Mitoxantrone and Examining Drug Sensitivity in BRCA1-Deficient Ovarian Cancer Using Quantitative Proteomics

<b>Background</b>: Mitoxantrone (MX) is regularly used to treat several cancers. Despite its long history in the clinic, recent studies continue to unveil novel protein targets. These targets may contribute to the cytotoxic effects of the drug, as well as potential non-canonical antitumor activity....

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Kaydedildi:
Asıl Yazarlar: Savanna Wallin, Sneha Pandithar, Sarbjit Singh, Siddhartha Kumar, Amarnath Natarajan, Gloria E. O. Borgstahl, Nicholas Woods
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2025-11-01
Seri Bilgileri:Proteomes
Konular:
mitoxantrone
homologous recombination-deficiency
ovarian cancer
BRCA1
DNA repair
proteomics
Online Erişim:https://www.mdpi.com/2227-7382/13/4/61
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