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Activation of rapid oestrogen signalling in aggressive human breast cancers

Abstract Oestrogen receptors can mediate rapid activation of cytoplasmic signalling cascades by recruiting Src and PI3K. However, the involvement of this pathway in breast cancer remains poorly defined. We have previously shown that methylation of ERα is required for the formation of the ERα/Src/PI3...

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Principais autores: Coralie Poulard, Isabelle Treilleux, Emilie Lavergne, Katia Bouchekioua‐Bouzaghou, Sophie Goddard‐Léon, Sylvie Chabaud, Olivier Trédan, Laura Corbo, Muriel Le Romancer
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2012-10-01
Serier:EMBO Molecular Medicine
Fag:
arginine methylation
breast cancer
oestrogen receptors
PI3K
Src tyrosine kinase
Online adgang:https://doi.org/10.1002/emmm.201201615
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