Arginine methylation regulates Ewing sarcoma cell viability in a EWSR1::FLI1 dependent manner and provides a therapeutic opportunity

IntroductionEwing sarcoma is a rare type of cancer arising from bone and soft tissues mainly affecting children and young adults. Treatments include intensive chemotherapy, surgery and radiotherapy, however more than 30% of patients die from the disease. Direct drug targeting of EWS-FLI1 remains a s...

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Hlavní autoři:	Ciara M. Ward, Charles Brockwell, Gavin S. McNee, Emily Orton, Emily N. P. Prowse, Susanne A. Gatz, Clare C. Davies
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-08-01
Edice:	Frontiers in Oncology
Témata:	Ewing sarcoma PRMT1 PRMT5 arginine methylation DNA damage olaparib
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1538208/full
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