Arginine methylation regulates Ewing sarcoma cell viability in a EWSR1::FLI1 dependent manner and provides a therapeutic opportunity

IntroductionEwing sarcoma is a rare type of cancer arising from bone and soft tissues mainly affecting children and young adults. Treatments include intensive chemotherapy, surgery and radiotherapy, however more than 30% of patients die from the disease. Direct drug targeting of EWS-FLI1 remains a s...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ciara M. Ward, Charles Brockwell, Gavin S. McNee, Emily Orton, Emily N. P. Prowse, Susanne A. Gatz, Clare C. Davies
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-08-01
Colecção:	Frontiers in Oncology
Assuntos:	Ewing sarcoma PRMT1 PRMT5 arginine methylation DNA damage olaparib
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1538208/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!