Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum

Abstract Background Despite having been extensively studied, it remains largely unclear why humans bear a particularly high risk of cancer. The antagonistic pleiotropy hypothesis predicts that primate-specific genes (PSGs) tend to promote tumorigenesis, while the molecular atavism hypothesis predict...

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Detalhes bibliográficos

Principais autores:	Chenyu Ma, Chunyan Li, Huijing Ma, Daqi Yu, Yufei Zhang, Dan Zhang, Tianhan Su, Jianmin Wu, Xiaoyue Wang, Li Zhang, Chun-Long Chen, Yong E. Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-12-01
coleção:	Genome Biology
Assuntos:	Molecular atavism Antagonistic pleiotropy Primate-specific genes Cancer evolution Brain evolution Cell cycle
Acesso em linha:	https://doi.org/10.1186/s13059-022-02821-9
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