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Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse

Abstract Background Mitral valve prolapse (MVP) is a common heart disorder characterized by an excessive production of proteoglycans and extracellular matrix in mitral valve leaflets. Large-scale genome-wide association study (GWAS) underlined that MVP is heritable. The molecular underpinnings of th...

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Autors principals: Louis-Hippolyte Minvielle Moncla, Mewen Briend, Mame Sokhna Sylla, Samuel Mathieu, Anne Rufiange, Yohan Bossé, Patrick Mathieu
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2024-06-01
Col·lecció:Communications Medicine
Accés en línia:https://doi.org/10.1038/s43856-024-00530-x
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