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The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy

Summary: The multiple roles of TGR5 in the regulation of glucose metabolism, inflammation, and oxidative stress have drawn attention as therapeutic candidates for diabetes-related kidney disease. However, diabetes induces downregulation of renal TGR5 protein expression, and the regulatory mechanisms...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Zeyuan Lin, Shanshan Li, Haiming Xiao, Zhanchi Xu, Chuting Li, Jingran Zeng, Shaogui Wang, Zhongqiu Liu, Heqing Huang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2023-08-01
Rangatū:Cell Reports
Ngā marau:
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2211124723008628
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