Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction

Abstract Background AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. The zebrafish genome contains two ambra1 paralogous genes (a...

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Detalhes bibliográficos

Principais autores:	Camilla Maria Fontana, Francesca Terrin, Nicola Facchinello, Giacomo Meneghetti, Alberto Dinarello, Lisa Gambarotto, Annalisa Zuccarotto, Micol Caichiolo, Ginevra Brocca, Ranieri Verin, Francesca Nazio, Oliana Carnevali, Francesco Cecconi, Paolo Bonaldo, Luisa Dalla Valle
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-04-01
coleção:	Biological Research
Assuntos:	Ambra1 PGCs Sex differentiation Reproduction Zebrafish Mouse
Acesso em linha:	https://doi.org/10.1186/s40659-023-00430-9
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