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Downregulation of Ambra1 by altered DNA methylation exacerbates dopaminergic neuron damage in a fenpropathrin-induced Parkinson-like mouse model

Fenpropathrin (Fen), a volatile pyrethroid insecticide, is used widely for agricultural applications and has been reported to increase the risk of Parkinson’s disease (PD). However, the molecular basis, underlying mechanisms, and pathophysiology of Fen-exposed Parkinsonism remain unknown. Recent stu...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Songzhe He, Qi Qu, Xi Chen, Li Zhao, Zhigang Jiao, Zhiting Wan, Hang Fai Kwok, Shaogang Qu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-02-01
Schriftenreihe:Ecotoxicology and Environmental Safety
Schlagworte:
Parkinson’s disease
Dopaminergic neuron
Fenpropathrin
Ambra1
Mitophagy
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S0147651324000708
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